Pestivirus translation initiation occurs by internal ribosome entry
نویسندگان
چکیده
منابع مشابه
Mechanisms of internal ribosome entry in translation initiation.
eukaryotic translation initiation, the 40S ribo-somal subunit must be recruited to a messenger RNA (mRNA) and positioned at the correct initiation codon. In most mRNAs, this is achieved via a series of intermolec-ular events involving a group of protein factors that assemble on the capped 5énd of the mRNA. This assembly recruits the 40S ribosomal subunit and enables it to scan to the translatio...
متن کاملINITIATION FACTOR eIF2-INDEPENDENT MODE OF c-Src mRNA TRANSLATION OCCURS VIA AN INTERNAL RIBOSOME ENTRY SITE (IRES)
Overexpression and activation of c-Src protein have been linked to the development of a wide variety of cancers. The molecular mechanism(s) of c-Src overexpression in cancer cells is not clear. We report here an internal ribosome entry site (IRES) in the c-Src mRNA that is constituted by both 5’ noncoding and coding regions. The inhibition of capdependent translation by m 7 GDP in cell-free tra...
متن کاملInitiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site.
Overexpression and activation of the c-Src protein have been linked to the development of a wide variety of cancers. The molecular mechanism(s) of c-Src overexpression in cancer cells is not clear. We report here an internal ribosome entry site (IRES) in the c-Src mRNA that is constituted by both 5'-noncoding and -coding regions. The inhibition of cap-dependent translation by m(7)GDP in the cel...
متن کاملEukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation.
Numerous cellular mRNAs encoding proteins critical during cell stress, apoptosis, and the cell cycle seem to be translated by means of internal ribosome entry sequences (IRES) when cap-dependent translation is compromised. The underlying molecular mechanisms are largely unknown. Using a HeLa-based cell-free translation system that mirrors the function of cellular IRESs in vitro, we recently dem...
متن کاملInteraction of translation initiation factor eIF4B with the poliovirus internal ribosome entry site.
Poliovirus translation is initiated at the internal ribosome entry site (IRES). Most likely involving the action of standard initiation factors, this highly structured cis element in the 5" noncoding region of the viral RNA guides the ribosome to an internal silent AUG. The actual start codon for viral protein synthesis further downstream is then reached by ribosomal scanning. In this study we ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Virology
سال: 1995
ISSN: 0042-6822
DOI: 10.1016/s0042-6822(95)80003-4